ARF GTPases and their ubiquitous role in intracellular trafficking beyond the Golgi
P Adarska, L Wong-Dilworth… - Frontiers in cell and …, 2021 - frontiersin.org
Molecular switches of the ADP-ribosylation factor (ARF) GTPase family coordinate
intracellular trafficking at all sorting stations along the secretory pathway, from the ER-Golgi-
intermediate compartment (ERGIC) to the plasma membrane (PM). Their GDP-GTP switch is
essential to trigger numerous processes, including membrane deformation, cargo sorting
and recruitment of downstream coat proteins and effectors, such as lipid modifying enzymes.
While ARFs (in particular ARF1) had mainly been studied in the context of coat protein …
intracellular trafficking at all sorting stations along the secretory pathway, from the ER-Golgi-
intermediate compartment (ERGIC) to the plasma membrane (PM). Their GDP-GTP switch is
essential to trigger numerous processes, including membrane deformation, cargo sorting
and recruitment of downstream coat proteins and effectors, such as lipid modifying enzymes.
While ARFs (in particular ARF1) had mainly been studied in the context of coat protein …
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