Abandonment of Routine Radiotherapy for Nonlocally Advanced Rectal Cancer and Oncological Outcomes
SMJA Hazen, TC Sluckin, MPW Intven, GL Beets… - JAMA …, 2024 - jamanetwork.com
Importance Neoadjuvant short-course radiotherapy was routinely applied for nonlocally
advanced rectal cancer (cT1-3N0-1M0 with> 1 mm distance to the mesorectal fascia) in the
Netherlands following the Dutch total mesorectal excision trial. This policy has shifted toward
selective application after guideline revision in 2014. Objective To determine the association
of decreased use of neoadjuvant radiotherapy with cancer-related outcomes and overall
survival at a national level. Design, Setting, and Participants This multicenter, population …
advanced rectal cancer (cT1-3N0-1M0 with> 1 mm distance to the mesorectal fascia) in the
Netherlands following the Dutch total mesorectal excision trial. This policy has shifted toward
selective application after guideline revision in 2014. Objective To determine the association
of decreased use of neoadjuvant radiotherapy with cancer-related outcomes and overall
survival at a national level. Design, Setting, and Participants This multicenter, population …
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