Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood–brain barrier
Background A principal protective component of the mammalian blood–brain barrier (BBB)
is the high expression of the multidrug efflux transporters P-glycoprotein (P-gp, encoded by
ABCB1) and ABCG2 (encoded by ABCG2) on the lumenal surface of endothelial cells. The
zebrafish P-gp homolog Abcb4 is expressed at the BBB and phenocopies human P-gp.
Comparatively little is known about the four zebrafish homologs of the human ABCG2 gene:
abcg2a, abcg2b, abcg2c, and abcg2d. Here we report the functional characterization and …
is the high expression of the multidrug efflux transporters P-glycoprotein (P-gp, encoded by
ABCB1) and ABCG2 (encoded by ABCG2) on the lumenal surface of endothelial cells. The
zebrafish P-gp homolog Abcb4 is expressed at the BBB and phenocopies human P-gp.
Comparatively little is known about the four zebrafish homologs of the human ABCG2 gene:
abcg2a, abcg2b, abcg2c, and abcg2d. Here we report the functional characterization and …
Correction: Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood–brain barrier
… abcg2a and abcb4 are expressed in claudin-5 positive 5 dpf larval brain vasculature. A
Paraffin-embedded 5 dpf larval zebrafish sections were probed with RNAscope probes (yellow)
to detect abcg2a-d mRNA, an antibody against claudin-5 (green) and DAPI (blue). B Co-staining
of the abcg2a probed section with an abcb4 RNAscope probe. Scale bar = 100 μm, inset
scale bar = 10 μm …
Paraffin-embedded 5 dpf larval zebrafish sections were probed with RNAscope probes (yellow)
to detect abcg2a-d mRNA, an antibody against claudin-5 (green) and DAPI (blue). B Co-staining
of the abcg2a probed section with an abcb4 RNAscope probe. Scale bar = 100 μm, inset
scale bar = 10 μm …
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