Aberrant expression of miR-125a-3p promotes fibroblast activation via Fyn/STAT3 pathway during silica-induced pulmonary fibrosis
Q Xu, Y Liu, H Pan, T Xu, Y Li, J Yuan, P Li, W Yao… - Toxicology, 2019 - Elsevier
Various miRNAs are dysregulated during initiation and progression of pulmonary fibrosis.
However, their function remains limited in silicosis. Here, we observed that miR-125a-3p
was downregulated in silica-induced fibrotic murine lung tissues. Ectopic miR-125a-3p
expression with chemotherapy attenuated silica-induced pulmonary fibrosis. Further in vitro
experiments revealed that TGF-β1 effectively decreased miR-125a-3p expression in
fibroblast lines (NIH/3T3 and MRC-5). Overexpression of miR-125a-3p blocked fibroblast …
However, their function remains limited in silicosis. Here, we observed that miR-125a-3p
was downregulated in silica-induced fibrotic murine lung tissues. Ectopic miR-125a-3p
expression with chemotherapy attenuated silica-induced pulmonary fibrosis. Further in vitro
experiments revealed that TGF-β1 effectively decreased miR-125a-3p expression in
fibroblast lines (NIH/3T3 and MRC-5). Overexpression of miR-125a-3p blocked fibroblast …
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