Ability of Innate Defence Regulator Peptides IDR-1002, IDR-HH2 and IDR-1018 to Protect against Mycobacterium tuberculosis Infections in Animal Models

B Rivas-Santiago, JE Castañeda-Delgado… - PloS one, 2013 - journals.plos.org
peptides [14,16,17,19; Table 1]. Intriguingly the two active peptides, IDR-HH2 and IDR-1018
inactive IDR-1002 (Table 1). However we cannot exclude that differential activity related to …

The innate defense regulator peptides IDR-HH2, IDR-1002, and IDR-1018 modulate human neutrophil functions

F Niyonsaba, L Madera, N Afacan… - Journal of leukocyte …, 2013 - academic.oup.com
… The ability of the IDR peptides to regulate the expression of the neutrophil adhesion
molecules and activation markers was supported first by the observation that these …

[PDF][PDF] Ability of Innate Defence Regulator Peptides IDR-1002

B Rivas-Santiago… - … to Protect against …, 2013 - pdfs.semanticscholar.org
… , IDR-HH2 and IDR-1018 to protect against Mycobacterium tuberculosis infections in animal
… The innate defense regulator peptides IDR-HH2, IDR-1002, and IDR-1018 modulate human …

Immunomodulatory innate defence regulator (IDR) peptide alleviates airway inflammation and hyper-responsiveness

H Piyadasa, M Hemshekhar, A Altieri, S Basu… - Thorax, 2018 - thorax.bmj.com
… We also show that IDR-1002 exhibits the ability to reduce AHR induced by either HDM, IL-33
or … . The innate defense regulator peptides IDR-HH2, IDR-1002, and IDR-1018 modulate …

Mechanisms of immune response regulation by innate defense regulator peptides

L Madera - 2012 - open.library.ubc.ca
… study, IDR1002 was found to be a multi-faceted regulator of … Similarly, synergy between
IDR-HH2, a structurally-related … Likewise, IDR-1018 and IDR-HH2 also demonstrate the ability to …

Biodistribution and toxicity of innate defense regulator 1018 (IDR-1018)

TVF Esposito, C Rodriguez-Rodriguez… - European Journal of …, 2022 - Elsevier
… The radiotracer used in this study consists of the IDR-1018 peptide … In mice, 67 Ga-NOTA-IDR-1018
was rapidly cleared from the … network, and the ability of IDR-1018 to interact with cell …

Innate defense regulator peptide 1018 protects against perinatal brain injury

H Bolouri, K Sävman, W Wang, A Thomas… - Annals of …, 2014 - Wiley Online Library
… based on their superior ability to induce chemokines and suppress … IDR-HH2 reduced
LPS-induced TNF-α production but not the … to determine whether IDR-1018 and/or IDR-1002 could …

Mechanisms of the innate defense regulator peptide-1002 anti-inflammatory activity in a sterile inflammation mouse model

BC Wu, AHY Lee, REW Hancock - The Journal of Immunology, 2017 - journals.aai.org
… on peptide IDR-1002, which has been demonstrated to promote in vivo protective innate
immunity … This highlights the ability of IDR-1002 to differentially modulate the immune response …

[PDF][PDF] Ability of Innate Defence Regulator Peptides

B Rivas-Santiago, JE Castaneda-Delgado… - pone …, 2013 - academia.edu
peptides [14,16,17,19; Table 1]. Intriguingly the two active peptides, IDR-HH2 and IDR-1018
inactive IDR-1002 (Table 1). However we cannot exclude that differential activity related to …

Disrupting Tryptophan in the Central Hydrophobic Region selectively mitigates immunomodulatory activities of the Innate Defence Regulator peptide IDR-1002

H Piyadasa, M Hemshekhar, N Osawa… - Journal of Medicinal …, 2021 - ACS Publications
peptides IDR-1002 and IDR-1002.2(W8/R) in the HDM-challenged mouse model. The route
of administration and peptide … of IDR-1002 altered the ability of the peptide to prevent AHR, …