Abnormal motility in patients with ulcerative colitis: the role of inflammatory cytokines
MD Vrees, VE Pricolo, FM Potenti, W Cao - Archives of Surgery, 2002 - jamanetwork.com
Hypothesis Interleukin 1β (IL-1β) levels are elevated in the colonic mucosa of patients with
ulcerative colitis (UC). We propose that IL-1β may also be elevated in the circular muscle
layer of the colon and may be partially responsible for the motility dysfunction observed in
patients with UC. Design Cohort analytic study. Setting Research laboratory in a tertiary
academic medical center. Participants Normal smooth muscle was obtained from the
disease-free margins of human sigmoid colon specimens resected from patients with cancer …
ulcerative colitis (UC). We propose that IL-1β may also be elevated in the circular muscle
layer of the colon and may be partially responsible for the motility dysfunction observed in
patients with UC. Design Cohort analytic study. Setting Research laboratory in a tertiary
academic medical center. Participants Normal smooth muscle was obtained from the
disease-free margins of human sigmoid colon specimens resected from patients with cancer …
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