[HTML][HTML] Accelerated tumor growth under intermittent hypoxia is associated with hypoxia-inducible factor-1-dependent adaptive responses to hypoxia
Mounting evidence has revealed a causative role of intermittent hypoxia (IH) in cancer
progression in mouse models of obstructive sleep apnea (OSA), but most studies have
focused on the effects of IH following tumor implantation using an exposure to single IH
frequency. Thus, we aimed to investigate 1) the potential effect of IH on the initial tumor
growth in patients with OSA without an interaction with other mechanisms induced by IH in
mice and 2) the influence of the IH frequency on tumor growth, which were tested using pre …
progression in mouse models of obstructive sleep apnea (OSA), but most studies have
focused on the effects of IH following tumor implantation using an exposure to single IH
frequency. Thus, we aimed to investigate 1) the potential effect of IH on the initial tumor
growth in patients with OSA without an interaction with other mechanisms induced by IH in
mice and 2) the influence of the IH frequency on tumor growth, which were tested using pre …
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