Nowadays, academicians from Malaysian research university experience greater levels of burnout due to their high extents of job demands and low levels of job resources. Therefore, this study aims to examine the role of Acceptance and Commitment Therapy (ACT) in reducing burnout level of an academician from Malaysian research university. A systematic search of the literature was conducted, and two studies identified which met the criteria for inclusion in the review. The results of the study demonstrated that ACT plays the role to reduce burnout level of the respondent while observing improved psychological flexibility. The findings of the study are helpful to both academics and practitioners who desire to manage burnout pervasiveness among academicians from Malaysian research university.