Accurate ethnicity prediction from placental DNA methylation data
Background The influence of genetics on variation in DNA methylation (DNAme) is well
documented. Yet confounding from population stratification is often unaccounted for in
DNAme association studies. Existing approaches to address confounding by population
stratification using DNAme data may not generalize to populations or tissues outside those
in which they were developed. To aid future placental DNAme studies in assessing
population stratification, we developed an ethnicity classifier, PlaNET (Placental DNAme …
documented. Yet confounding from population stratification is often unaccounted for in
DNAme association studies. Existing approaches to address confounding by population
stratification using DNAme data may not generalize to populations or tissues outside those
in which they were developed. To aid future placental DNAme studies in assessing
population stratification, we developed an ethnicity classifier, PlaNET (Placental DNAme …
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