The integration of various access networks into a ubiquitous, yet heterogeneous, wireless environment is on the way. This evolution of the mobile network will give the end-user a greater choice of access technologies, and, therefore, the decision to select the “best” interface and access network from many possible combinations has to be taken. The decision will depend on information such as: performances and capabilities of the available networks, requirements from applications, user preferences, or network operators’ constraints. Our work focuses on an advanced middleware which deals with profile management to support the interface automatic configuration and selection. Furthermore, the proposed mechanism supports the dynamic (re)mapping of the application flows by taking into consideration multiple selection criteria.