Action potential block in neurons by infrared light
Short infrared laser pulses (SILP) have many physiological effects on cells, including the
ability to stimulate action potentials (APs) in neurons. Here, we show that SILPs can also
reversibly block APs. Reversible AP block in hippocampal neurons was observed following
SILP (0.26 to 0.96 J/cm 2; 1.37 to 5.01 ms; 1869 nm) with the block persisting for more than 1
s with exposures greater than 0.69 J/cm 2. AP block was sustained for 30 s with SILPs
pulsed at 1 to 7 Hz. Full recovery of neuronal activity was observed 5 to 30 s post SILP …
ability to stimulate action potentials (APs) in neurons. Here, we show that SILPs can also
reversibly block APs. Reversible AP block in hippocampal neurons was observed following
SILP (0.26 to 0.96 J/cm 2; 1.37 to 5.01 ms; 1869 nm) with the block persisting for more than 1
s with exposures greater than 0.69 J/cm 2. AP block was sustained for 30 s with SILPs
pulsed at 1 to 7 Hz. Full recovery of neuronal activity was observed 5 to 30 s post SILP …
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