Activation of T cells by carbamazepine and carbamazepine metabolites
Y Wu, JP Sanderson, J Farrell, NS Drummond… - Journal of allergy and …, 2006 - Elsevier
BACKGROUND: T-cell–mediated hypersensitivity is a rare but serious manifestation of drug
therapy. OBJECTIVES: To explore the mechanisms of drug presentation to T cells and the
possibility that generation of metabolite-specific T cells may provoke cross-sensitization
between drugs. METHODS: A lymphocyte transformation test was performed on 13
hypersensitive patients with carbamazepine, oxcarbazepine, and carbamazepine
metabolites. Serial dilution experiments were performed to generate drug (metabolite) …
therapy. OBJECTIVES: To explore the mechanisms of drug presentation to T cells and the
possibility that generation of metabolite-specific T cells may provoke cross-sensitization
between drugs. METHODS: A lymphocyte transformation test was performed on 13
hypersensitive patients with carbamazepine, oxcarbazepine, and carbamazepine
metabolites. Serial dilution experiments were performed to generate drug (metabolite) …
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