The fine control of synaptic function requires robust trans-synaptic molecular interactions.
However, it remains poorly understood how trans-synaptic bridges change to reflect the
functional states of the synapse. Here, we develop optical tools to visualize in firing
synapses the molecular behavior of two trans-synaptic proteins, LGI1 and ADAM23, and find
that neuronal activity acutely rearranges their abundance at the synaptic cleft. Surprisingly,
synaptic LGI1 is primarily not secreted, as described elsewhere, but exo-and endocytosed …

The fine control of synaptic function requires robust transsynaptic molecular interactions.
However, it remains poorly understood how the landscape of trans-synaptic bridges
dynamically remodels to reflect functional states of the synapse. Here we developed novel
optical tools to visualize in firing synapses the molecular behavior of a particular secreted
trans-synaptic protein, LGI1, and its presynaptic receptor, ADAM23, and discovered that
neuronal activity acutely rearranges the abundance of these proteins at the synaptic cleft …