Acute increases of renal medullary osmolality stimulate endothelin release from the kidney
EI Boesen, DM Pollock - American Journal of Physiology …, 2007 - journals.physiology.org
Experiments conducted in vitro suggest that high osmolality stimulates endothelin
production and release by renal tubular epithelial cells. Whether hyperosmotic solutions
exert similar effects in vivo is unknown. Therefore, we tested the hypothesis that increasing
renal medullary osmolality enhances urinary excretion of endothelin in anesthetized rats.
Isosmotic NaCl (284 mosmol/kgH2O) was infused either intravenously (1.5 ml/h) or into the
renal medullary interstitium (0.5 ml/h) during a 1-h equilibration period and 30-min baseline …
production and release by renal tubular epithelial cells. Whether hyperosmotic solutions
exert similar effects in vivo is unknown. Therefore, we tested the hypothesis that increasing
renal medullary osmolality enhances urinary excretion of endothelin in anesthetized rats.
Isosmotic NaCl (284 mosmol/kgH2O) was infused either intravenously (1.5 ml/h) or into the
renal medullary interstitium (0.5 ml/h) during a 1-h equilibration period and 30-min baseline …
Acute increases of renal medullary osmolality stimulate endothelin release from
EI Boesen, DM Pollock - Am J Hypertens, 1995 - journals.physiology.org
Experiments conducted in vitro suggest that high osmolality stimulates endothelin
production and release by renal tubular epithelial cells. Whether hyperosmotic solutions
exert similar effects in vivo is unknown. Therefore we tested the hypothesis that increasing
renal medullary osmolality enhances urinary excretion of endothelin in anesthetized rats.
Isosmotic NaCl (284 mOsmol/kg H2O) was infused either intravenously (1.5 ml/h) or into the
renal medullary interstitium (0.5 ml/h) during a 1 h equilibration period and 30 min baseline …
production and release by renal tubular epithelial cells. Whether hyperosmotic solutions
exert similar effects in vivo is unknown. Therefore we tested the hypothesis that increasing
renal medullary osmolality enhances urinary excretion of endothelin in anesthetized rats.
Isosmotic NaCl (284 mOsmol/kg H2O) was infused either intravenously (1.5 ml/h) or into the
renal medullary interstitium (0.5 ml/h) during a 1 h equilibration period and 30 min baseline …
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