Acute neurological adverse events during immune checkpoint inhibition therapy in patients with melanoma brain metastases
V Grätz, EA Langan, A Neumann, D Zillikens… - Melanoma …, 2019 - journals.lww.com
The common adverse effects of immune checkpoint blockade therapy are well recognised.
However, neurological adverse effects of checkpoint inhibitor therapy are less widely
appreciated, and their clinical management remains challenging. Therefore, we report our
experience of managing acute, life-threatening neurological toxicity during immune
checkpoint inhibitor therapy. Five male patients with stage IV melanoma underwent anti-
programmed cell death protein 1 therapy (monotherapy or combination therapy with anti …
However, neurological adverse effects of checkpoint inhibitor therapy are less widely
appreciated, and their clinical management remains challenging. Therefore, we report our
experience of managing acute, life-threatening neurological toxicity during immune
checkpoint inhibitor therapy. Five male patients with stage IV melanoma underwent anti-
programmed cell death protein 1 therapy (monotherapy or combination therapy with anti …
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