Acute oral toxicity: variability, reliability, relevance and interspecies comparison of rodent LD50 data from literature surveyed for the ACuteTox project
S Hoffmann, A Kinsner-Ovaskainen, P Prieto… - Regulatory Toxicology …, 2010 - Elsevier
The ACuteTox project has aimed to optimise and prevalidate an in vitro testing strategy for
predicting human acute toxicity. Ninety-seven reference substances were selected and an in
vivo acute toxicity database was compiled. Comprehensive statistical analyses of the in vivo
LD50 data to evaluate variability and reliability, interspecies correlation, predictive
capacities with regard to EU and GHS toxicity categories, and deduction of performance
criteria for in vitro methods is presented. For the majority of substances variability among …
predicting human acute toxicity. Ninety-seven reference substances were selected and an in
vivo acute toxicity database was compiled. Comprehensive statistical analyses of the in vivo
LD50 data to evaluate variability and reliability, interspecies correlation, predictive
capacities with regard to EU and GHS toxicity categories, and deduction of performance
criteria for in vitro methods is presented. For the majority of substances variability among …
[引用][C] Acute oral toxicity: Variability, reliability, relevance and interspecies comparison of rodent LD50 data from literature surveyed for the ACuteTox project
A KINSNER-OVASKAINEN, PMDP PRIETO… - publications.jrc.ec.europa.eu
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