Acute toxicity effects of the methanolic extract of Fagara zanthoxyloides (Lam.) root-bark
JW Ogwal-Okeng, C Obua, WW Anokbonggo - African Health Sciences, 2003 - ajol.info
JW Ogwal-Okeng, C Obua, WW Anokbonggo
African Health Sciences, 2003•ajol.infoBackground: Fagara zanthoxyloides is a well known medicinal plant in Uganda. It is used
extensively in malaria and other infections. However nothing is known about its toxicity.
Objective: The objective of the study was to evaluate the acute toxicity of the methanolic
extract of the root-bark of F. zanthoxyloides, in mice. Methods: Methanolic extract of the root-
bark of the plant was administered orally to mice at various dose levels to determine the
acute toxic effects and the median lethal dose (LD50) in mice. Results: The LD50 of the …
extensively in malaria and other infections. However nothing is known about its toxicity.
Objective: The objective of the study was to evaluate the acute toxicity of the methanolic
extract of the root-bark of F. zanthoxyloides, in mice. Methods: Methanolic extract of the root-
bark of the plant was administered orally to mice at various dose levels to determine the
acute toxic effects and the median lethal dose (LD50) in mice. Results: The LD50 of the …
Abstract
Background: Fagara zanthoxyloides is a well known medicinal plant in Uganda. It is used extensively in malaria and other infections. However nothing is known about its toxicity.
Objective: The objective of the study was to evaluate the acute toxicity of the methanolic extract of the root-bark of F. zanthoxyloides, in mice.
Methods: Methanolic extract of the root-bark of the plant was administered orally to mice at various dose levels to determine the acute toxic effects and the median lethal dose (LD50) in mice.
Results: The LD50 of the methanolic extract was found to be5. 0 g/Kg body weight within 95% confidence limits. The mice showed signs of cerebral irritation before dying. Histopathological examinations of the viscera showed congestion and focal necrosis of the liver and renal tubules.
Conclusion: It was concluded that the extract of F. zanthoxyloides is safe, however the cerebral mechanism that lead to the death of the mice need to be investigated further.
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