Triacylglycerol (TG) is a storage lipid which serves as an energy reservoir and a source of
signalling molecules and substrates for membrane biogenesis. TG is essential for many
physiological processes and its metabolism is widely conserved in nature. Acyl-CoA:
diacylglycerol acyltransferase (DGAT, EC 2.3. 1.20) catalyzes the final step in the sn-glycerol-
3-phosphate pathway leading to TG. DGAT activity resides mainly in two distinct membrane
bound polypeptides, known as DGAT1 and DGAT2 which have been identified in numerous …