Background—Adropin is a recently identified protein that has been implicated in the
maintenance of energy homeostasis and insulin resistance. Because vascular function and
insulin sensitivity are closely related, we hypothesized that adropin may also exert direct
effects on the endothelium. Methods and Results—In vitro cell culture models were
partnered with an in vivo murine injury model to determine the potential vascular effects of
adropin. Adropin was expressed in human umbilical vein and coronary artery endothelial …

Adropin is a recently identified protein that has been implicated in the maintenance of
energy homeostasis and insulin resistance. Inasmuch as vascular function and insulin
sensitivity are closely related, we hypothesized that adropin may also exert direct effects on
the endothelium. In vitro cell culture models were partnered with an in vivo murine injury
model to determine the potential vascular effects of adropin. Adropin was expressed in
human venous and coronary artery endothelial cells. Endothelial cells treated with adropin …