Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney are the same disease entity: molecular and histologic evidence
Adult cystic nephroma (CN) and mixed epithelial and stromal tumor of the kidney (MEST) are
considered as separate entities in the 2004 World Health Organization classification of renal
neoplasms. Recent studies suggested that the two share clinicopathologic features and may
represent the same disease process of varying morphology. However, definitive genetic
evidence is lacking. We examined their relationship using gene expression profiling and
histologic analysis. Gene expression profiles of 3 CN and 3 MEST were analyzed using …
considered as separate entities in the 2004 World Health Organization classification of renal
neoplasms. Recent studies suggested that the two share clinicopathologic features and may
represent the same disease process of varying morphology. However, definitive genetic
evidence is lacking. We examined their relationship using gene expression profiling and
histologic analysis. Gene expression profiles of 3 CN and 3 MEST were analyzed using …