Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE)
MD Oldfield, LA Bach, JM Forbes… - The Journal of …, 2001 - Am Soc Clin Investig
Tubulointerstitial disease, a prominent phenomenon in diabetic nephropathy, correlates with
decline in renal function. The underlying pathogenic link between chronic hyperglycemia
and the development of tubulointerstitial injury has not been fully elucidated, but
myofibroblast formation represents a key step in the development of tubulointerstitial fibrosis.
RAGE, the receptor for advanced glycation end products (AGEs), induces the expression of
TGF-β and other cytokines that are proposed to mediate the transdifferentiation of epithelial …
decline in renal function. The underlying pathogenic link between chronic hyperglycemia
and the development of tubulointerstitial injury has not been fully elucidated, but
myofibroblast formation represents a key step in the development of tubulointerstitial fibrosis.
RAGE, the receptor for advanced glycation end products (AGEs), induces the expression of
TGF-β and other cytokines that are proposed to mediate the transdifferentiation of epithelial …
Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE).
LA Bach, D Nikolic-Paterson, ME Cooper, G Jerums… - 2012 - repository.monashhealth.org
Tubulointerstitial disease, a prominent phenomenon in diabetic nephropathy, correlates with
decline in renal function. The underlying pathogenic link between chronic hyperglycemia
and the development of tubulointerstitial injury has not been fully elucidated, but
myofibroblast formation represents a key step in the development of tubulointerstitial fibrosis.
RAGE, the receptor for advanced glycation end products (AGEs), induces the expression of
TGF-beta and other cytokines that are proposed to mediate the transdifferentiation of …
decline in renal function. The underlying pathogenic link between chronic hyperglycemia
and the development of tubulointerstitial injury has not been fully elucidated, but
myofibroblast formation represents a key step in the development of tubulointerstitial fibrosis.
RAGE, the receptor for advanced glycation end products (AGEs), induces the expression of
TGF-beta and other cytokines that are proposed to mediate the transdifferentiation of …
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