Decreased beta-amyloid clearance in Alzheimer's disease and increased blood-brain
barrier permeability in aged subjects have been reported in several articles. However,
morphological and functional characterization of blood-brain barrier and its membrane
transporter activity have not been described in physiological aging yet. The aim of our study
was to explore the structural changes in the brain microvessels and possible functional
alterations of P-glycoprotein at the blood-brain barrier with aging. Our approach included …