[HTML][HTML] Age-specific patterns of DBLα var diversity can explain why residents of high malaria transmission areas remain susceptible to Plasmodium falciparum blood …
Immunity to Plasmodium falciparum is non-sterilising, thus individuals residing in malaria-
endemic areas are at risk of infection throughout their lifetime. Here we seek to find a
genomic epidemiological explanation for why residents of all ages harbour blood stage
infections despite lifelong exposure to P. falciparum in areas of high transmission. We do
this by exploring, for the first known time, the age-specific patterns of diversity of variant
antigen encoding (var) genes in the reservoir of infection. Microscopic and submicroscopic …
endemic areas are at risk of infection throughout their lifetime. Here we seek to find a
genomic epidemiological explanation for why residents of all ages harbour blood stage
infections despite lifelong exposure to P. falciparum in areas of high transmission. We do
this by exploring, for the first known time, the age-specific patterns of diversity of variant
antigen encoding (var) genes in the reservoir of infection. Microscopic and submicroscopic …