Agonist-induced signaling, desensitization, and internalization of a phosphorylation-deficient AT1A angiotensin receptor
JA Olivares-Reyes, RD Smith, L Hunyady… - Journal of Biological …, 2001 - ASBMB
An analysis of the functional role of a diacidic motif (Asp 236-Asp 237) in the third
intracellular loop of the AT 1A angiotensin II (Ang II) receptor (AT 1-R) revealed that
substitution of both amino acids with alanine (DD-AA) or asparagine (DD-NN) residues
diminished Ang II-induced receptor phosphorylation in COS-7 cells. However, Ang II-
stimulated inositol phosphate production, mitogen-activated protein kinase, and AT 1
receptor desensitization and internalization were not significantly impaired. Overexpression …
intracellular loop of the AT 1A angiotensin II (Ang II) receptor (AT 1-R) revealed that
substitution of both amino acids with alanine (DD-AA) or asparagine (DD-NN) residues
diminished Ang II-induced receptor phosphorylation in COS-7 cells. However, Ang II-
stimulated inositol phosphate production, mitogen-activated protein kinase, and AT 1
receptor desensitization and internalization were not significantly impaired. Overexpression …
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