Alkyne-Forming Furan Fragmentation: A General Method to Convert Furans into Alkynoic Acids
J Deng, J Gui - Synlett, 2019 - thieme-connect.com
J Deng, J Gui
Synlett, 2019•thieme-connect.comFurans are readily available and highly reactive heterocycles that serve as versatile four-
carbon synthons in organic synthesis. Recently, we discovered that furans, upon oxidation
with singlet oxygen, can be transformed into alkynes via dual C–C double-bond cleavage.
This Synpacts article presents an overview of the historical context and the development of
this furan fragmentation reaction. We also discuss its application in natural product synthesis
and a plausible reaction mechanism. 1 Introduction 2 Background of Alkyne-Forming Furan …
carbon synthons in organic synthesis. Recently, we discovered that furans, upon oxidation
with singlet oxygen, can be transformed into alkynes via dual C–C double-bond cleavage.
This Synpacts article presents an overview of the historical context and the development of
this furan fragmentation reaction. We also discuss its application in natural product synthesis
and a plausible reaction mechanism. 1 Introduction 2 Background of Alkyne-Forming Furan …
Furans are readily available and highly reactive heterocycles that serve as versatile four-carbon synthons in organic synthesis. Recently, we discovered that furans, upon oxidation with singlet oxygen, can be transformed into alkynes via dual C–C double-bond cleavage. This Synpacts article presents an overview of the historical context and the development of this furan fragmentation reaction. We also discuss its application in natural product synthesis and a plausible reaction mechanism.
1 Introduction
2 Background of Alkyne-Forming Furan Fragmentation
3 Reaction Development
4 Conclusion
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