Allelic loss of 8p sequences in prostatic intraepithelial neoplasia and carcinoma
MJ Häggman, KJ Wojno, CP Pearsall, JA Macoska - Urology, 1997 - Elsevier
OBJECTIVES: Previous work has suggested that prostatic intraepithelial neoplasia (PIN)
may be a premalignant lesion important in tumorigenesis of the prostate. However, to
adequately test this hypothesis at the genetic level, it is necessary to determine whether
lesions in close proximity demonstrate similar genetic alterations and, hence, whether an
“evolutionary” relationship might exist between PIN and tumor in the same prostate.
Therefore, the purpose of this study was to examine at least two PIN lesions per prostate …
may be a premalignant lesion important in tumorigenesis of the prostate. However, to
adequately test this hypothesis at the genetic level, it is necessary to determine whether
lesions in close proximity demonstrate similar genetic alterations and, hence, whether an
“evolutionary” relationship might exist between PIN and tumor in the same prostate.
Therefore, the purpose of this study was to examine at least two PIN lesions per prostate …
以上显示的是最相近的搜索结果。 查看全部搜索结果