Birch pollinosis is often accompanied by hypersensitivity to fruit as a consequence of the
cross-reaction of pollen allergen-specific IgE antibodies with homologous food proteins. To
provide a basis for examining the cross-reactivity on a structural level, we used
heteronuclear multidimensional NMR spectroscopy to determine the high-resolution three-
dimensional structure of the major cherry allergen, Pru av 1, in solution. Based on a detailed
comparison of the virtually identical structures of Pru av 1 and Bet v 1, the major birch pollen …