Allopregnanolone elevations following pregnenolone administration are associated with enhanced activation of emotion regulation neurocircuits
BACKGROUND: The neurosteroid allopregnanolone is a potent allosteric modulator of the
gamma-aminobutyric acid type A receptor with anxiolytic properties. Exogenous
administration of allopregnanolone reduces anxiety, and allopregnanolone blockade
impairs social and affective functioning. However, the neural mechanism whereby
allopregnanolone improves mood and reduces anxiety is unknown. In particular, brain
imaging has not been used to link neurosteroid effects to emotion regulation neurocircuitry …
gamma-aminobutyric acid type A receptor with anxiolytic properties. Exogenous
administration of allopregnanolone reduces anxiety, and allopregnanolone blockade
impairs social and affective functioning. However, the neural mechanism whereby
allopregnanolone improves mood and reduces anxiety is unknown. In particular, brain
imaging has not been used to link neurosteroid effects to emotion regulation neurocircuitry …
以上显示的是最相近的搜索结果。 查看全部搜索结果