… , and endogenous CB1R allosteric ligands have been identified. The paradigmatic, first-generation
CB1R allosteric modulators, Org27569 and PSNCBAM-1, paradoxically enhance the …

… of cannabinoid receptors. In this paper, we present the latest advances in research on the
CB1R, its allosteric modulation and allosteric … essentials of the cannabinoid 1 receptor- ligand (…

… a potent allosteric modulator for the cannabinoid receptor 1 (… improve allosteric parameters
for the cannabinoid receptor 1 (… Allosteric modulators of the cannabinoid 1 receptor. Patent. …

… In this study, the primary effect of CBD at CB 1 receptors was negative allosteric
modulation at concentrations below 1 μM. The studies by Price et al. (2005) and Baillie et al. …

… of novel CB1R allosteric modulators as … 1), exhibiting enantiospecific allosteric CB1R
modulation. As an ago-PAM, the resolved R-(+)-enantiomer (GAT228, 7) is a partial allosteric …

… vitro and in vivo pharmacology of CB 1 allosteric modulators. We will discuss the challenges
… It has been speculated that pregnenolone may show probe dependence (ie THC versus 2-…

… This review details the complex pharmacological profiles of these allosteric modulators, …
reported CB1 allosteric modulators. The ultimate development of CB1 receptor allosteric ligands …

… To gain a better molecular understanding of the interaction and mechanism of these allosteric
modulators, we determined the crystal structure of CB1 with the agonists CP55940 and …

… In this review, we summarize the concept of allosteric modulation and focus … allosteric
modulators, ORG27569 and PSNCBAM-1 and their derivatives, and a few other recent modulators. …

… -generation of allosteric modulators of CB 1 receptor, their structure-… and the allosteric binding
site(s) on the CB 1 receptor. … on the allosteric modulation of the CB 1 receptor and gives a …