Alternative splicing of SLC39A14 in colorectal cancer is regulated by the Wnt pathway
K Thorsen, F Mansilla, T Schepeler, B Øster… - Molecular & Cellular …, 2011 - ASBMB
Alternative splicing is a crucial step in the generation of protein diversity and its
misregulation is observed in many human cancer types. By analyzing 143 colorectal
samples using exon arrays, SLC39A14, a divalent cation transporter, was identified as being
aberrantly spliced in tumor samples. SLC39A14 contains two mutually exclusive exons 4A
and 4B and the exon 4A/4B ratio was significantly altered in adenomas (p= 3.6× 10− 10) and
cancers (p= 9.4× 10− 11), independent of microsatellite stability status. The findings were …
misregulation is observed in many human cancer types. By analyzing 143 colorectal
samples using exon arrays, SLC39A14, a divalent cation transporter, was identified as being
aberrantly spliced in tumor samples. SLC39A14 contains two mutually exclusive exons 4A
and 4B and the exon 4A/4B ratio was significantly altered in adenomas (p= 3.6× 10− 10) and
cancers (p= 9.4× 10− 11), independent of microsatellite stability status. The findings were …
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