Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer.
H Zhang, Y Yang, JL Horton… - The Journal of …, 1997 - Am Soc Clin Investig
Both rheumatoid arthritis and animal models of autoimmune arthritis are characterized by
hyperactivation of synovial cells and hyperplasia of the synovial membrane. The activated
synovial cells produce inflammatory cytokines and degradative enzymes that lead to
destruction of cartilage and bones. Effective treatment of arthritis may require elimination of
most or all activated synovial cells. The death factor Fas/Apo-1 and its ligand (FasL) play
pivotal roles in maintaining self-tolerance and immune privilege. Fas is expressed …
hyperactivation of synovial cells and hyperplasia of the synovial membrane. The activated
synovial cells produce inflammatory cytokines and degradative enzymes that lead to
destruction of cartilage and bones. Effective treatment of arthritis may require elimination of
most or all activated synovial cells. The death factor Fas/Apo-1 and its ligand (FasL) play
pivotal roles in maintaining self-tolerance and immune privilege. Fas is expressed …
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