Amelioration of dextran sulfate colitis by butyrate: role of heat shock protein 70 and NF-κB
A Venkatraman, BS Ramakrishna… - American Journal …, 2003 - journals.physiology.org
Butyrate enemas have been demonstrated to ameliorate inflammation in ulcerative colitis.
The mechanism of this protective effect of butyrate is not known, and this study examines the
effect of butyrate on epithelial function, inducible heat shock protein 70 (HSP70) expression,
and NF-κB activation in experimental colitis. Colitis was induced in rats by oral dextran
sulfate sodium (DSS) and by butyrate or saline enemas. Mucosal barrier function was
assessed by electrical resistance and [14C] mannitol permeability. HSP70 production was …
The mechanism of this protective effect of butyrate is not known, and this study examines the
effect of butyrate on epithelial function, inducible heat shock protein 70 (HSP70) expression,
and NF-κB activation in experimental colitis. Colitis was induced in rats by oral dextran
sulfate sodium (DSS) and by butyrate or saline enemas. Mucosal barrier function was
assessed by electrical resistance and [14C] mannitol permeability. HSP70 production was …
[PDF][PDF] Amelioration of dextran sulfate colitis by butyrate
P Diets - Am J Physiol Gastrointest Liver Physiol, 2005 - academia.edu
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Copyright© 2003 by the American Physiological abnormal function of the gastrointestinal
tract, hepatobiliary system, and pancreas. It is published 12 times a year (monthly) by the
publishes original articles pertaining to all aspects of research involving normal or
American Physiological Society, 9650 Rockville Pike, Bethesda MD 20814-3991.
Copyright© 2003 by the American Physiological abnormal function of the gastrointestinal
tract, hepatobiliary system, and pancreas. It is published 12 times a year (monthly) by the
publishes original articles pertaining to all aspects of research involving normal or
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