Amide pharmacophore has gained significant consideration in the field of current medicinal chemistry. Literature indicates that compounds having amide pharmacophore have wide range of pharmacological activities, viz., anticonvulsant, antitubercular, antimicrobial, analgesic and anti‐inflammatory, insecticidal, antitumor, fibrinolytic, and antiplatelet aggregatory. This chapter focuses on the anticonvulsant activity of substituted amides. The well‐known and recent data on the preparation of amides used in the synthesis of these biologically active anticonvulsant compounds are summarized. The favorable amide derivatives possessing anticonvulsant activity will reignite the interest of medicinal chemists in amide and its derivatives.