Aminocaproic acid decreases the incidence of intracranial hemorrhage and other hemorrhagic complications of ECMO

JM Wilson, LK Bower, JC Fackler, DA Beals… - Journal of pediatric …, 1993 - Elsevier
Since the inception of extracorporeal membrane oxygenation (ECMO), hemorrhage has
been a major complication often limiting its usefulness. This study was undertaken to
evaluate the effect of aminocaproic acid (AMICAR), an inhibitor of fibrinolysis, on all
hemorrhagic complications of ECMO including intracranial hemorrhage (ICH). In 1990, 49
neonates and 5 older children received ECMO therapy. None of these patients received
AMICAR. In 1991, 51 neonates and 5 older children received ECMO. Forty-two of these …
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