Amplatzer PFO occluder device may prevent recurrent stroke in patients with patent foramen ovale and cryptogenic stroke: a meta-analysis of randomised trials
Objective To review efficacy of percutaneous closure of patent foramen ovale compared with
medical therapy in prevention of recurrent strokes in patients with cryptogenic stroke.
Methods and Results Electronic databases; PUBMED, EMBASE, Cochrane registry and web
of knowledge were searched for relevant studies. In three randomised clinical trials involving
2303 participants, risk of the recurrent strokes (pooled HR 0.62, 95% CI= 0.36-1.07, P= 0.09,
I 2= 10%) did not show benefit with device closure when compared with medical therapy …
medical therapy in prevention of recurrent strokes in patients with cryptogenic stroke.
Methods and Results Electronic databases; PUBMED, EMBASE, Cochrane registry and web
of knowledge were searched for relevant studies. In three randomised clinical trials involving
2303 participants, risk of the recurrent strokes (pooled HR 0.62, 95% CI= 0.36-1.07, P= 0.09,
I 2= 10%) did not show benefit with device closure when compared with medical therapy …
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