Amplified DNA sensing and immunosensing by the rotation of functional magnetic particles

Y Weizmann, F Patolsky, E Katz… - Journal of the American …, 2003 - ACS Publications
Journal of the American Chemical Society, 2003ACS Publications
… We were able to demonstrate the magnetic switching of the bioelectrocatalytic functions
of redox-enzymes using relay-modified magnetite particles 11 and to highlight the magnetic
switching of the biocatalyzed generation of electrochemiluminescence using quinone-functionalized
magnetite particles and the horseradish peroxidase (HRP)/luminol system. Recently, we
demonstrated that the rotation of magnetic particles on electrode surfaces by means of an
external rotating magnet leads to amplified bioelectrocatalysis due to a convection-controlled …
Amplified chemiluminescent detection of DNA−complementary DNA or of antigen−antibody interactions is accomplished in the presence of rotating functionalized magnetic particles.
ACS Publications
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