Amyloid duration is associated with preclinical cognitive decline and tau PET
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020•Wiley Online Library
Introduction This study applies a novel algorithm to longitudinal amyloid positron emission
tomography (PET) imaging to identify age‐heterogeneous amyloid trajectory groups,
estimate the age and duration (chronicity) of amyloid positivity, and investigate chronicity in
relation to cognitive decline and tau burden. Methods Cognitively unimpaired participants
(n= 257) underwent one to four amyloid PET scans (Pittsburgh Compound B, PiB). Group‐
based trajectory modeling was applied to participants with longitudinal scans (n= 171) to …
tomography (PET) imaging to identify age‐heterogeneous amyloid trajectory groups,
estimate the age and duration (chronicity) of amyloid positivity, and investigate chronicity in
relation to cognitive decline and tau burden. Methods Cognitively unimpaired participants
(n= 257) underwent one to four amyloid PET scans (Pittsburgh Compound B, PiB). Group‐
based trajectory modeling was applied to participants with longitudinal scans (n= 171) to …
Introduction
This study applies a novel algorithm to longitudinal amyloid positron emission tomography (PET) imaging to identify age‐heterogeneous amyloid trajectory groups, estimate the age and duration (chronicity) of amyloid positivity, and investigate chronicity in relation to cognitive decline and tau burden.
Methods
Cognitively unimpaired participants (n = 257) underwent one to four amyloid PET scans (Pittsburgh Compound B, PiB). Group‐based trajectory modeling was applied to participants with longitudinal scans (n = 171) to identify and model amyloid trajectory groups, which were combined with Bayes theorem to estimate age and chronicity of amyloid positivity. Relationships between chronicity, cognition, clinical progression, and tau PET (MK‐6240) were investigated using regression models.
Results
Chronicity explained more heterogeneity in amyloid burden than age and binary amyloid status. Chronicity was associated with faster cognitive decline, increased risk of abnormal cognition, and higher entorhinal tau.
Discussion
Amyloid chronicity provides unique information about cognitive decline and neurofibrillary tangle development and may be useful to investigate preclinical Alzheimer's disease.
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