The E2F family of transcription factors is essential in the regulation of the cell cycle and
apoptosis. While the activity of E2F1–3 is tightly controlled by the retinoblastoma family of
proteins, the expression of these factors is also regulated at the level of transcription, post-
translational modifications and protein stability. Recently, a new level of regulation of E2Fs
has been identified, where micro-RNAs (miRNAs) from the mir-17–92 cluster influence the
translation of the E2F1 mRNA. We now report that miR-20a, a member of the mir-17–92 …