An Improved Synthesis of Multi-Substituted Pyrazines under Catalyst-and Solvent-Free Conditions
F Tamaddon, AD Tafti, F Pooramini - Synthesis, 2016 - thieme-connect.com
F Tamaddon, AD Tafti, F Pooramini
Synthesis, 2016•thieme-connect.comA one-pot pseudo four-component reaction between a variety of 2-hydroxy-1, 2-
diarylethanone derivatives and ammonium acetate or amines has been developed to
synthesize substituted pyrazines under catalyst-free and solvent-free conditions. This
procedure provides a synthetic method to access pyrazine derivatives in excellent yields
under green conditions.
diarylethanone derivatives and ammonium acetate or amines has been developed to
synthesize substituted pyrazines under catalyst-free and solvent-free conditions. This
procedure provides a synthetic method to access pyrazine derivatives in excellent yields
under green conditions.
A one-pot pseudo four-component reaction between a variety of 2-hydroxy-1,2-diarylethanone derivatives and ammonium acetate or amines has been developed to synthesize substituted pyrazines under catalyst-free and solvent-free conditions. This procedure provides a synthetic method to access pyrazine derivatives in excellent yields under green conditions.
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