An NMR-based Model of the Ubiquitin-bound Human Ubiquitin Conjugation Complex Mms2· Ubc13: THE STRUCTURAL BASIS FOR LYSINE 63 CHAIN CATALYSIS …
A heterodimer composed of the catalytically active ubiquitin-conjugating enzyme hUbc13
and its catalytically inactive paralogue, hMms2, forms the catalytic core for the synthesis of
an alternative type of multiubiquitin chain where ubiquitin molecules are tandemly linked to
one another through a Lys-63 isopeptide bond. This type of linkage, as opposed to the more
typical Lys-48-linked chains, serves as a non-proteolytic marker of protein targets involved in
error-free post-replicative DNA repair and NF-κB signal transduction. Using a two …
and its catalytically inactive paralogue, hMms2, forms the catalytic core for the synthesis of
an alternative type of multiubiquitin chain where ubiquitin molecules are tandemly linked to
one another through a Lys-63 isopeptide bond. This type of linkage, as opposed to the more
typical Lys-48-linked chains, serves as a non-proteolytic marker of protein targets involved in
error-free post-replicative DNA repair and NF-κB signal transduction. Using a two …
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