Problems arise as a result of the use of hazardous solvents, excessive use of energy, waste creation, and other aspects of industrial activity. As an example, the chemical synthesis of many of the active medicinal compounds, we used benzimidazole derivatives. These benzimidazole compounds have a wide range of applications in the medical community. A major problem for the pharmaceutical sector is that present methods that don't correspond to the green chemistry principles take too long and hurt the environment. Simple Nanoparticles Synthesized from Plant Extract and supported on Montmorillonite K10 catalyzed approach can be used to synthesize benzimidazole derivatives. Heterogeneous catalysis employing nanoparticles synthesized from plant extract and supported on Montmorillonite K10 provides several advantages: high reaction yields, simple and appropriate reaction workup procedures, improved selectivity, and the demonstration of catalyst recycling without waste formation. The reactions were carried out without the use of any solvents thanks to a low-cost and ecologically friendly heterogeneous catalysis approach. It has been proven that the reaction process can be used in industry.