An RNA tertiary switch by modifying how helices are tethered
Genome biology, 2014•Springer
… A recent paper by Kieft and colleagues [[3]] reveals a viral RNA structure that has
modified the way in which its secondary structure helices are tethered together, thereby
achieving a unique capacity to act as a tertiary conformational switch that may help regulate
viral replication and translation. … In a canonical tRNA secondary structure architecture,
disrupting three-dimensional structure would require energetically costly disruption of
multiple secondary structure helices. Altering the secondary structure connectivity and using …
modified the way in which its secondary structure helices are tethered together, thereby
achieving a unique capacity to act as a tertiary conformational switch that may help regulate
viral replication and translation. … In a canonical tRNA secondary structure architecture,
disrupting three-dimensional structure would require energetically costly disruption of
multiple secondary structure helices. Altering the secondary structure connectivity and using …
Abstract
A viral tRNA-like structure has evolved a unique strategy to undergo a tertiary structure conformational switch that may help regulate viral regulation.
Springer
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