[PDF][PDF] An association between bioavailable 25-hydroxyvitamin D and bone mineral density in a diverse cohort of collegiate athletes
MS Rockwell, SB Kostelnik, RP McMillan… - Medicine & Science in …, 2022 - sportsrd.org
Medicine & Science in Sports & Exercise, 2022•sportsrd.org
ABSTRACT ROCKWELL, MS, SB KOSTELNIK, RP MCMILLAN, M. LANCASTER, DE
LARSON-MEYER, and MW HULVER. An Association between Bioavailable 25-
Hydroxyvitamin D and Bone Mineral Density in a Diverse Cohort of Collegiate Athletes. Med.
Sci. Sports Exerc., Vol. 54, No. 3, pp. 371n376, 2022. Introduction: Although vitamin D is
intimately involved in bone metabolism, the relationship between vitamin D status, as
measured by serum total 25-hydroxyvitamin D [25 (OH) D] concentration, and bone mineral …
LARSON-MEYER, and MW HULVER. An Association between Bioavailable 25-
Hydroxyvitamin D and Bone Mineral Density in a Diverse Cohort of Collegiate Athletes. Med.
Sci. Sports Exerc., Vol. 54, No. 3, pp. 371n376, 2022. Introduction: Although vitamin D is
intimately involved in bone metabolism, the relationship between vitamin D status, as
measured by serum total 25-hydroxyvitamin D [25 (OH) D] concentration, and bone mineral …
Abstract
ROCKWELL, MS, SB KOSTELNIK, RP MCMILLAN, M. LANCASTER, DE LARSON-MEYER, and MW HULVER. An Association between Bioavailable 25-Hydroxyvitamin D and Bone Mineral Density in a Diverse Cohort of Collegiate Athletes. Med. Sci. Sports Exerc., Vol. 54, No. 3, pp. 371n376, 2022.
Introduction
Although vitamin D is intimately involved in bone metabolism, the relationship between vitamin D status, as measured by serum total 25-hydroxyvitamin D [25 (OH) D] concentration, and bone mineral density (BMD) is weak, particularly in non-White populations. Measurement of bioavailable 25 (OH) D has been suggested as a better indicator of vitamin D status than total 25 (OH) D concentration. To date, the bioavailable 25 (OH) D biomarker has been explored minimally in athletic populations. The purpose of this study was to investigate the relationship between total and bioavailable 25 (OH) D concentrations and BMD in collegiate athletes. Methods
NCAA Division I basketball and swimming athletes served as study participants (n= 53; 28 females, 25 males; 28 basketball players, 25 swimmers). All participants completed dual-energy x-ray absorptiometry scans for analysis of BMD, blood draws for vitamin D measures, and diet/lifestyle questionnaires. Results
Overall, total 25 (OH) D was 80.0+ 13.9 nmol· L− 1 and bioavailable 25 (OH) D was 6.0±1.9 nmol· L− 1. There was strong disagreement between total 25 (OH) D and bioavailable 25 (OH) D concentrations (κ=− 0.299, r=− 0.129)(P= 0.100); 53% of total participants and 77% of Black participants were classified differently (low vs normal vitamin D status) based on total and bioavailable 25 (OH) D criteria. Black participants had significantly lower total 25 (OH) D and higher bioavailable 25 (OH) D concentrations than White participants (59.5 vs 102.5 nmol· L− 1 and 7.9 vs 5.4 nmol· L− 1, respectively)(P< 0.001). Total 25 (OH) D and total BMD were not correlated, but bioavailable 25 (OH) D and total BMD demonstrated a positive correlation (r= 0.618, P< 0.01). Conclusions
These results suggest that bioavailable 25 (OH) D concentration may be a better clinical measure of vitamin D status than total 25 (OH) D as related to BMD in collegiate athletes, particularly in Black athletes. Further research on the utility of the bioavailable 25 (OH) D biomarker in athletes is needed. Key Words: VITAMIN D,sportsrd.org
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