Life extension is an attractive option for subsea flexible risers nearing the end of their design lives. However, techniques for assessing accumulated fatigue damage in flexible risers are often associated with large uncertainties due to the simplified calculation approaches typically used. One approach to reducing uncertainties is the inclusion of nonlinearities in riser structural response and consistent linking between global and local models. In this article, we present the elements of a numerical multiscale procedure capable of predicting the stresses that lead to fatigue damage in flexible pipes, namely: a nonlinear beam element, a nonlinear section response model and a detailed finite element model; the consistent integration of models developed for different length scales; and finally a validation of the flexible riser large-scale model.