Adoptive transfer of antigen-specific T cells represents a major advance in cancer
immunotherapy, with robust clinical outcomes in some patients. Both the number of
transferred T cells and their differentiation state are critical determinants of effective
responses,. T cells can be expanded with T cell receptor (TCR)-mediated stimulation and
interleukin-2, but this can lead to differentiation into effector T cells, and lower therapeutic
efficacy, whereas maintenance of a more stem-cell-like state before adoptive transfer is …

Adoptive cell transfer of antigen specific T cells represents a major advance in cancer
immunotherapy, with robust clinical outcomes in a subset of patients. To achieve effective
responses, both the number of transferred T cells and their cell differentiation state are
critical determinants. T cells can be expanded with T cell receptor (TCR)-mediated
stimulation and IL-2 but this can also lead to T cell differentiation into effector T cells,
resulting in diminished therapeutic efficacy, whereas maintenance of a more stem-like prior …