This paper focuses on the valuation of refurbishment costs for healthcare facilities. The determination of the more reliable approach for experimental verification is a research topic of great interest, especially because previous literature on the matter is limited. This study examines ex-ante cost valuations in the refurbishment of healthcare buildings while using similarity to estimate the costs that are based on the amount of already accomplished renovations. The methodology involved a desk analysis deter-mining the technical valuation of intervention needs, and similarity coefficient applications providing a refurbishment cost valuation. The application was conducted in the Friuli—Venezia Giulia Region in Italy, where hospitals show structural, layout, and plants deficits with respect to current regulations, and a technical deepening to identify critical issues is required to prepare a multi-year intervention plan. The case study results showed that this procedure requires little initial information to run analyses and its application can support investment budget planning purposes.