[HTML][HTML] An isogenic hiPSC-derived BBB-on-a-chip
P Motallebnejad, A Thomas, SL Swisher, SM Azarin - Biomicrofluidics, 2019 - pubs.aip.org
The blood-brain barrier (BBB) is composed of brain microvascular endothelial cells (BMECs)
that regulate brain homeostasis, and astrocytes within the brain are involved in the
maintenance of the BBB or modulation of its integrity in disease states via secreted factors. A
major challenge in modeling the normal or diseased BBB is that conventional in vitro models
lack either the physiological complexity of the BBB or key functional features such as
formation of a sufficiently tight barrier. In this study, we utilized human induced pluripotent …
that regulate brain homeostasis, and astrocytes within the brain are involved in the
maintenance of the BBB or modulation of its integrity in disease states via secreted factors. A
major challenge in modeling the normal or diseased BBB is that conventional in vitro models
lack either the physiological complexity of the BBB or key functional features such as
formation of a sufficiently tight barrier. In this study, we utilized human induced pluripotent …
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