An optrode array for spatiotemporally-precise large-scale optogenetic stimulation of deep cortical layers in non-human primates
Optogenetics has transformed studies of neural circuit function, but remains challenging to
apply to non-human primates (NHPs). A major challenge is delivering intense,
spatiotemporally-precise, patterned photostimulation across large volumes in deep tissue.
Such stimulation is critical, for example, to modulate selectively deep-layer corticocortical
feedback circuits. To address this need, we have developed the Utah Optrode Array (UOA),
a 10× 10 glass needle waveguide array fabricated atop a novel opaque optical interposer …
apply to non-human primates (NHPs). A major challenge is delivering intense,
spatiotemporally-precise, patterned photostimulation across large volumes in deep tissue.
Such stimulation is critical, for example, to modulate selectively deep-layer corticocortical
feedback circuits. To address this need, we have developed the Utah Optrode Array (UOA),
a 10× 10 glass needle waveguide array fabricated atop a novel opaque optical interposer …
[HTML][HTML] An Optrode Array for Spatiotemporally Precise Large-Scale Optogenetic Stimulation of Deep Cortical Layers in Non-human Primates
A Angelucci, A Clark, A Ingold, C Reiche… - Research …, 2023 - ncbi.nlm.nih.gov
Optogenetics has transformed studies of neural circuit function, but remains challenging to
apply in non-human primates (NHPs). A major challenge is delivering intense and spatially
precise patterned photostimulation across large volumes in deep tissue. Here, we have
developed and validated the Utah Optrode Array (UOA) to meet this critical need. The UOA
is a 10× 10 glass waveguide array bonded to an electrically-addressable μLED array. In vivo
electrophysiology and immediate early gene (c-fos) immunohistochemistry demonstrated …
apply in non-human primates (NHPs). A major challenge is delivering intense and spatially
precise patterned photostimulation across large volumes in deep tissue. Here, we have
developed and validated the Utah Optrode Array (UOA) to meet this critical need. The UOA
is a 10× 10 glass waveguide array bonded to an electrically-addressable μLED array. In vivo
electrophysiology and immediate early gene (c-fos) immunohistochemistry demonstrated …