… Page 3 In this overview of tyrosine site-specific recombination, we present our current … from
biochemical, chemical, structural and topological perspectives, and highlight the utility of this …

… In this overview of tyrosine site-specific recombination, we … , structural and topological
perspectives, and highlight the … Strand cleavage by the active site tyrosine nucleophile utilizes …

… Here, we review the recombination mechanisms of the best characterized … phage integrases
as examples of tyrosine-type phage integrases, (2) Cre and Flp … Conclusion and perspective …

… bases of the site specific recombination reaction of these … Although the tyrosine recombinases
Cre, Flp, and Int share little … This approach results in a recombinase consisting of a …

… This review presents the current state of knowledge and … shown to approach 100% conversion
of substrates to recombinant … FLP is a 45-kDa tyrosine recombinase encoded by the yeast …

… Flp, a tyrosine site-specific recombinase coded for by the selfish two micron plasmid of …
INTRODUCTION … event is remarkable from a chemical perspective. Reversibility is easier to …

… Tyrosine site-specific recombinases, which promote one class of … Flp active site is assembled
by the donation of the tyrosine … and Flp recombinases provide a stereochemical view of the …

… This chapter shall provide a brief historical perspective on the … technologies to the introduction
of transgenes in human … Flp belong to the tyrosine class of site-specific recombinases …

… focused on tyrosine and serine site-specific recombinases. Their pre-… tyrosine site-specific
recombinases (Cre and Flp) and one serine … Stepwise view of Flp recombination by TPM. The …

… the λ phage integrase, a tyrosine-type recombinase that acts in a … on the yeast FLP/FRT
site-specific recombination system in … of this approach uses a site-specific recombinase, the …