An unexpected, novel, three-component reaction between isoquinoline, an isocyanide and strong CH-acids in water
A Shaabani, E Soleimani, HR Khavasi - Tetrahedron Letters, 2007 - Elsevier
… An unexpected three-component condensation reaction between an isocyanide,
isoquinoline and a strong CH-acid efficiently provides 1,2-dihydroisoquinoline derivatives in
a one-pot reaction in water at 70 C without using any catalyst. … The reactivity of
isocyanides or nitrogen-containing heterocycles such as isoquinoline as nucleophiles with
activated alkynes in the presence of strong CH-acids is well documented. The … To the
best of our knowledge, there has not been any report on the reaction between isocyanide …
isoquinoline and a strong CH-acid efficiently provides 1,2-dihydroisoquinoline derivatives in
a one-pot reaction in water at 70 C without using any catalyst. … The reactivity of
isocyanides or nitrogen-containing heterocycles such as isoquinoline as nucleophiles with
activated alkynes in the presence of strong CH-acids is well documented. The … To the
best of our knowledge, there has not been any report on the reaction between isocyanide …
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